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SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.6
USERS' SCORE
Good
Based on 5 Reviews
8.7
Supplement Facts
Serving Size: 1 Veggie Capsule
Serving Per Container: 60
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
200 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
9
Coenzyme Q10 improves liver health
Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with metabolic-dysfunction associated steatotic liver disease: a randomized double-blind, placebo-controlled trial.
Significant findings for liver disease
We conducted a study to explore the effects of high-dose coenzyme Q10 supplementation on patients suffering from liver disease related to metabolic dysfunction, known as Metabolic-dysfunction Associated Steatotic Liver Disease (MASLD). In a well-structured double-blind, placebo-controlled trial with sixty participants, half received 240 mg of coenzyme Q10 daily, while the other half received a placebo for six months.
Our findings were promising. Patients taking coenzyme Q10 showed significant improvements in various aspects of their health related to liver functions and cardiovascular health. Specifically, we observed a reduction in liver fat content, as assessed by the controlled attenuation parameter, along with better blood vessel function and heart performance. For instance, the flow-mediated dilation of the brachial artery and the coronary flow reserve significantly improved in those receiving the supplement.
Interestingly, while the placebo group did not show any improvements during the six-month period, the coenzyme Q10 group demonstrated a clear correlation between the reduction in liver fat and enhancements in micro- and macrovascular functions. These results suggest that coenzyme Q10 could potentially be a beneficial treatment option for those battling MASLD.
Our findings were promising. Patients taking coenzyme Q10 showed significant improvements in various aspects of their health related to liver functions and cardiovascular health. Specifically, we observed a reduction in liver fat content, as assessed by the controlled attenuation parameter, along with better blood vessel function and heart performance. For instance, the flow-mediated dilation of the brachial artery and the coronary flow reserve significantly improved in those receiving the supplement.
Interestingly, while the placebo group did not show any improvements during the six-month period, the coenzyme Q10 group demonstrated a clear correlation between the reduction in liver fat and enhancements in micro- and macrovascular functions. These results suggest that coenzyme Q10 could potentially be a beneficial treatment option for those battling MASLD.
Read More
9
CoQ10 protects against liver damage
Effects of idebenone and coenzyme Q10 on NLRP3/caspase-1/IL-1β pathway regulation on ethanol-induced hepatotoxicity in rats.
Direct relevance to CoQ10 effects
We explored the detrimental effects of chronic alcohol consumption on liver health, particularly focusing on how coenzyme Q10 (CoQ10) might help mitigate this damage. By conducting a study with rats, we investigated the relationship between ethanol-induced hepatotoxicity and the activation of specific inflammatory pathways.
The study involved giving rats increasing doses of ethanol over 30 days to induce liver damage, followed by treatment with CoQ10 in varying doses. We measured several liver health indicators and observed how CoQ10 affected inflammation and oxidative stress related to liver toxicity.
Our findings revealed that CoQ10 treatment significantly reduced liver damage markers and inflammation levels linked to the NLRP3/caspase-1/IL-1β pathway. Notably, we discovered that CoQ10 was more effective than its analog, idebenone (IDE), in protecting the liver from the harmful effects of alcohol.
This research is promising, as it highlights CoQ10's potential to serve as a therapeutic option for treating liver disease caused by alcohol consumption, shedding light on its antioxidant and anti-inflammatory properties.
The study involved giving rats increasing doses of ethanol over 30 days to induce liver damage, followed by treatment with CoQ10 in varying doses. We measured several liver health indicators and observed how CoQ10 affected inflammation and oxidative stress related to liver toxicity.
Our findings revealed that CoQ10 treatment significantly reduced liver damage markers and inflammation levels linked to the NLRP3/caspase-1/IL-1β pathway. Notably, we discovered that CoQ10 was more effective than its analog, idebenone (IDE), in protecting the liver from the harmful effects of alcohol.
This research is promising, as it highlights CoQ10's potential to serve as a therapeutic option for treating liver disease caused by alcohol consumption, shedding light on its antioxidant and anti-inflammatory properties.
Read More
4
CoQ10's variable effects on NAFLD
Effects of coenzyme Q10 supplementation on lipid profiles and liver enzymes of nonalcoholic fatty liver disease (NAFLD) patients: A systematic review and meta-analysis of randomized controlled trials.
Directly addresses CoQ10's impact
We aimed to understand how coenzyme Q10, an antioxidant, might influence patients suffering from non-alcoholic fatty liver disease (NAFLD). In our systematic review and meta-analysis, we examined various randomized controlled trials that utilized CoQ10 as part of the treatment regimen for NAFLD.
The findings from the six studies we reviewed showed an overall non-significant decrease in lipid profiles, which includes total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides. Additionally, liver enzymes such as aspartate transaminase and alanine transaminase tended to decline as well, but these results did not reach statistical significance across the board.
However, when we performed sensitivity analysis by excluding certain studies, we noted significant reductions in specific liver enzymes. Our subgroup analyses even revealed that the effects of coenzyme Q10 varied based on the dosage given and the duration of treatment. Despite these nuances, no publication bias was detected, reinforcing the reliability of the existing studies.
Overall, while there isn't a broad significant benefit observed from CoQ10 supplementation for NAFLD patients, our findings suggest that it may have beneficial effects under certain conditions. This indicates a need for further research to uncover the specific circumstances in which CoQ10 might be effective.
The findings from the six studies we reviewed showed an overall non-significant decrease in lipid profiles, which includes total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides. Additionally, liver enzymes such as aspartate transaminase and alanine transaminase tended to decline as well, but these results did not reach statistical significance across the board.
However, when we performed sensitivity analysis by excluding certain studies, we noted significant reductions in specific liver enzymes. Our subgroup analyses even revealed that the effects of coenzyme Q10 varied based on the dosage given and the duration of treatment. Despite these nuances, no publication bias was detected, reinforcing the reliability of the existing studies.
Overall, while there isn't a broad significant benefit observed from CoQ10 supplementation for NAFLD patients, our findings suggest that it may have beneficial effects under certain conditions. This indicates a need for further research to uncover the specific circumstances in which CoQ10 might be effective.
Read More
Most Useful Reviews
9.5
Promotes detoxification
Q10 is a powerful antioxidant that protects against free radicals, crucial for liver disease. I ordered it for my mother, who needed detox support, and it significantly boosts energy levels and reduces fatigue.
Read More
9.5
Reduced side effects
For those experiencing side effects from statins, Q10 is invaluable. It alleviates the liver disease load and lessens side effects. I have been taking it for over a year and am pleased with the results.
Read More
8.8
Supports liver health
I recommend CoQ10, which helps offset the negatives of cholesterol tablets I'm using. It reassures me that my liver is functioning well, thanks to regular tests with my naturopath.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.6
9
CoQ10 and Se improve liver health
Coenzyme Q and Selenium Co-Supplementation Alleviate Methionine Choline-Deficient Diet-Induced Metabolic Dysfunction-Associated Steatohepatitis in Mice.
Study shows combined antioxidant benefits
We explored the potential of coenzyme Q10 (CoQ) in combination with selenium (Se) to improve liver health in a mouse model of metabolic dysfunction-associated steatohepatitis (MASH). Our recent study involved male C57BL/6J mice fed a methionine choline-deficient diet, known to induce liver problems. The treatment groups received CoQ, Se, or both substances together for four weeks, while a control group received a methionine choline-sufficient diet.
The results revealed that both CoQ and Se, particularly when used in combination, significantly reduced liver inflammation, fibrosis, and fat accumulation. We observed that these antioxidants alleviated oxidative stress and decreased markers of lipid peroxidation, alongside improving liver enzyme levels in the mice's blood. Importantly, the combination therapy also appeared to support cellular health by regulating proteins related to a specific type of cell death known as ferroptosis.
Our findings suggest that CoQ, especially in tandem with selenium, has therapeutic potential for managing liver diseases like MASH. This research opens doors for deeper investigations into antioxidant treatments for liver health, showcasing how we might leverage natural compounds for better outcomes in metabolic liver conditions.
The results revealed that both CoQ and Se, particularly when used in combination, significantly reduced liver inflammation, fibrosis, and fat accumulation. We observed that these antioxidants alleviated oxidative stress and decreased markers of lipid peroxidation, alongside improving liver enzyme levels in the mice's blood. Importantly, the combination therapy also appeared to support cellular health by regulating proteins related to a specific type of cell death known as ferroptosis.
Our findings suggest that CoQ, especially in tandem with selenium, has therapeutic potential for managing liver diseases like MASH. This research opens doors for deeper investigations into antioxidant treatments for liver health, showcasing how we might leverage natural compounds for better outcomes in metabolic liver conditions.
Read More
9
Coenzyme Q10 improves liver health
Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with metabolic-dysfunction associated steatotic liver disease: a randomized double-blind, placebo-controlled trial.
Significant findings for liver disease
We conducted a study to explore the effects of high-dose coenzyme Q10 supplementation on patients suffering from liver disease related to metabolic dysfunction, known as Metabolic-dysfunction Associated Steatotic Liver Disease (MASLD). In a well-structured double-blind, placebo-controlled trial with sixty participants, half received 240 mg of coenzyme Q10 daily, while the other half received a placebo for six months.
Our findings were promising. Patients taking coenzyme Q10 showed significant improvements in various aspects of their health related to liver functions and cardiovascular health. Specifically, we observed a reduction in liver fat content, as assessed by the controlled attenuation parameter, along with better blood vessel function and heart performance. For instance, the flow-mediated dilation of the brachial artery and the coronary flow reserve significantly improved in those receiving the supplement.
Interestingly, while the placebo group did not show any improvements during the six-month period, the coenzyme Q10 group demonstrated a clear correlation between the reduction in liver fat and enhancements in micro- and macrovascular functions. These results suggest that coenzyme Q10 could potentially be a beneficial treatment option for those battling MASLD.
Our findings were promising. Patients taking coenzyme Q10 showed significant improvements in various aspects of their health related to liver functions and cardiovascular health. Specifically, we observed a reduction in liver fat content, as assessed by the controlled attenuation parameter, along with better blood vessel function and heart performance. For instance, the flow-mediated dilation of the brachial artery and the coronary flow reserve significantly improved in those receiving the supplement.
Interestingly, while the placebo group did not show any improvements during the six-month period, the coenzyme Q10 group demonstrated a clear correlation between the reduction in liver fat and enhancements in micro- and macrovascular functions. These results suggest that coenzyme Q10 could potentially be a beneficial treatment option for those battling MASLD.
Read More
9
CoQ10 protects against liver damage
Effects of idebenone and coenzyme Q10 on NLRP3/caspase-1/IL-1β pathway regulation on ethanol-induced hepatotoxicity in rats.
Direct relevance to CoQ10 effects
We explored the detrimental effects of chronic alcohol consumption on liver health, particularly focusing on how coenzyme Q10 (CoQ10) might help mitigate this damage. By conducting a study with rats, we investigated the relationship between ethanol-induced hepatotoxicity and the activation of specific inflammatory pathways.
The study involved giving rats increasing doses of ethanol over 30 days to induce liver damage, followed by treatment with CoQ10 in varying doses. We measured several liver health indicators and observed how CoQ10 affected inflammation and oxidative stress related to liver toxicity.
Our findings revealed that CoQ10 treatment significantly reduced liver damage markers and inflammation levels linked to the NLRP3/caspase-1/IL-1β pathway. Notably, we discovered that CoQ10 was more effective than its analog, idebenone (IDE), in protecting the liver from the harmful effects of alcohol.
This research is promising, as it highlights CoQ10's potential to serve as a therapeutic option for treating liver disease caused by alcohol consumption, shedding light on its antioxidant and anti-inflammatory properties.
The study involved giving rats increasing doses of ethanol over 30 days to induce liver damage, followed by treatment with CoQ10 in varying doses. We measured several liver health indicators and observed how CoQ10 affected inflammation and oxidative stress related to liver toxicity.
Our findings revealed that CoQ10 treatment significantly reduced liver damage markers and inflammation levels linked to the NLRP3/caspase-1/IL-1β pathway. Notably, we discovered that CoQ10 was more effective than its analog, idebenone (IDE), in protecting the liver from the harmful effects of alcohol.
This research is promising, as it highlights CoQ10's potential to serve as a therapeutic option for treating liver disease caused by alcohol consumption, shedding light on its antioxidant and anti-inflammatory properties.
Read More
9
CoQ10 shows protective potential
Evaluation of the protective effect of coenzyme Q on hepatotoxicity caused by acute phosphine poisoning.
Moderately relevant findings on CoQ10
We set out to explore how Coenzyme Q10 (CoQ) might guard against liver damage caused by aluminum phosphide (AlP) poisoning. This type of poisoning is a serious issue in many countries and can have dire consequences for organ health, especially the liver.
Our study involved several groups of subjects, some receiving CoQ treatment while others were exposed to AlP alone. We examined the effects of CoQ at various doses, looking closely at liver function and health indicators, such as certain enzymes and oxidative stress markers.
Our findings showed that AlP treatment led to significant liver damage, decreasing the activity of important mitochondrial components and raising oxidative stress levels. However, when we administered CoQ, we observed a noteworthy improvement in liver health markers and a reduction in apoptosis, or cell death. This suggests that CoQ may help support liver function by protecting against oxidative damage and maintaining mitochondrial health.
In summary, Coenzyme Q10 appears to play a beneficial role in combating liver toxicity caused by AlP poisoning, showcasing its potential as a protective treatment.
Our study involved several groups of subjects, some receiving CoQ treatment while others were exposed to AlP alone. We examined the effects of CoQ at various doses, looking closely at liver function and health indicators, such as certain enzymes and oxidative stress markers.
Our findings showed that AlP treatment led to significant liver damage, decreasing the activity of important mitochondrial components and raising oxidative stress levels. However, when we administered CoQ, we observed a noteworthy improvement in liver health markers and a reduction in apoptosis, or cell death. This suggests that CoQ may help support liver function by protecting against oxidative damage and maintaining mitochondrial health.
In summary, Coenzyme Q10 appears to play a beneficial role in combating liver toxicity caused by AlP poisoning, showcasing its potential as a protective treatment.
Read More
9
Coenzyme Q10 aids liver cancer treatment
Investigation of the effects of catharanthine and Q10 on Nrf2 and its association with MMP-9, MRP1, and Bcl-2 and apoptosis in a model of hepatocellular carcinoma.
Study relevant to liver disease
This study explored how coenzyme Q10 (Q10) affects liver disease, particularly in hepatocellular carcinoma cells known as HepG2. We found that Q10 serves as a potent antioxidant, showing promise in reducing oxidative stress in these cancer cells. Our analysis revealed that Q10 treatment led to decreased oxidative stress products and enhanced the cells' antioxidant capacity.
Interestingly, while Q10 reduced levels of the Nrf2 protein associated with cancer cell survival, another compound called catharanthine had the opposite effect by increasing Nrf2 levels. This distinction is crucial, as Nrf2 plays a role in how cancer cells respond to treatment. Notably, we observed that Q10 also lowered the expression of certain proteins linked to metastasis and drug resistance, namely MMP-9 and MRP1.
When it came to inducing apoptosis, or programmed cell death, both treatments did increase apoptotic activity, but Q10 proved to be more effective than catharanthine. In fact, our findings suggest that even when used together, the benefits of catharanthine were overshadowed by Q10's stronger effects. Overall, our results indicate that coenzyme Q10 is not only beneficial for reducing oxidative stress but also plays a significant role in inducing cell death in liver cancer cells, making it a valuable candidate for further research in liver disease treatment.
Interestingly, while Q10 reduced levels of the Nrf2 protein associated with cancer cell survival, another compound called catharanthine had the opposite effect by increasing Nrf2 levels. This distinction is crucial, as Nrf2 plays a role in how cancer cells respond to treatment. Notably, we observed that Q10 also lowered the expression of certain proteins linked to metastasis and drug resistance, namely MMP-9 and MRP1.
When it came to inducing apoptosis, or programmed cell death, both treatments did increase apoptotic activity, but Q10 proved to be more effective than catharanthine. In fact, our findings suggest that even when used together, the benefits of catharanthine were overshadowed by Q10's stronger effects. Overall, our results indicate that coenzyme Q10 is not only beneficial for reducing oxidative stress but also plays a significant role in inducing cell death in liver cancer cells, making it a valuable candidate for further research in liver disease treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.7
9.5
Reduced side effects
For those experiencing side effects from statins, Q10 is invaluable. It alleviates the liver disease load and lessens side effects. I have been taking it for over a year and am pleased with the results.
9.5
Promotes detoxification
Q10 is a powerful antioxidant that protects against free radicals, crucial for liver disease. I ordered it for my mother, who needed detox support, and it significantly boosts energy levels and reduces fatigue.
9
More energy
Coenzyme Q10 is beneficial for conditions like liver disease and chronic fatigue syndrome. I buy it for my mother-in-law, and she says it gives her a surge of energy, almost like rejuvenation.
9
Essential for health
Coenzyme Q10 is vital, especially as its levels drop after 35. It’s important for overall health and particularly beneficial for combating liver disease, making supplementation imperative.
8.8
Supports liver health
I recommend CoQ10, which helps offset the negatives of cholesterol tablets I'm using. It reassures me that my liver is functioning well, thanks to regular tests with my naturopath.
